Three prominent NFL players are expected to fail in Week 2 of fantasy football.

Brady has a poor record versus the Saints, losing the last four regular-season contests with two of Tampa Bay's victories coming by three points or fewer.

[{"selector":"#anim-015826e0-8c14-4a6b-af1f-430250b2590c","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-8a48c03c-ea53-4445-b05a-688ad0f257e3","keyframes":{"transform":["translate3d(0px, 152.52524%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}]

The Buccaneers also enter the game with a number of medical issues as receivers

[{"selector":"#anim-07307f05-e196-43e9-aca1-af2004d45a0c","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-61e75e70-9977-4954-a8d7-f0e84cb8a76e","keyframes":{"transform":["translate3d(0px, 220.67693%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}]

Chris Godwin, Russell Gage, Julio Jones, and Mike Evans are all either out or struggling with ailments, along with left tackle Donovan Smith.

[{"selector":"#anim-e1d74f49-6c8e-4c41-8435-9f49c9966f75","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-d34e30eb-1e11-4a61-999f-17701085072e","keyframes":{"transform":["translate3d(0px, 164.76363%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}]

Brady, who was Week 1's fantasy QB27, has consistently witnessed a decline in performance when Rob Gronkowski is out from the field.

[{"selector":"#anim-3aa46bd2-d2c6-4596-90e3-bd581ca490bb","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-11db58d6-c56f-4a67-86ca-77e0ac085420","keyframes":{"transform":["translate3d(0px, 158.81703%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}]

Henry didn't appear horrible in the Titans' season-opening defeat, but in his first game without AJ Brown, he only ran seven routes and didn't make a reception.

[{"selector":"#anim-c31700d4-18c6-459d-a758-2b9640db0fe5","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e6d2a327-7beb-4041-8ddf-57ee5b967da1","keyframes":{"transform":["translate3d(0px, 180.01088%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}]

Buffalo hosts Tennessee on Monday night in a challenging game; the Titans are 10-point underdogs.

[{"selector":"#anim-426b2e55-3fac-43ef-8e2f-008267ae9a33","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-529e657b-f7ab-48f8-b18c-65b26e0ebef1","keyframes":{"transform":["translate3d(0px, 173.75600%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}]

It's possible that Henry will see more third-down work as a result of Dontrell Hilliard's injury, but this week, Henry is more of an RB2 than a top-10 option.

[{"selector":"#anim-89a09c42-71e3-46a0-8be4-7606185057b1","keyframes":{"opacity":[0,1]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}] [{"selector":"#anim-e8e48b2d-d608-40be-b34d-87ee9793f68b","keyframes":{"transform":["translate3d(0px, 172.84610%, 0)","translate3d(0px, 0px, 0)"]},"delay":0,"duration":600,"easing":"cubic-bezier(0.2, 0.6, 0.0, 1)","fill":"both"}]